Adderall® CII is a pharmaceutical amphetamine used to treat attention-deficit hyperactivity disorder and narcolepsy. It was first prescribed in the 1970s as an anorectic (under the brand name Obetrol®), but such usage is now rare.

Use

Adderall is a central nervous system stimulant composed of four amphetamine salts: amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate, and dextroamphetamine sulfate (the last salt is also prescribed alone as Dexedrine®). The four component salts are claimed to be metabolised at different rates.

The average elimination half-life for dextroamphetamine is 10 hours in adults, and for levoamphetamine, 13 hours. Its effects are otherwise similar to other central nervous system stimulants (see amphetamine for details.).

The manufacturer claims that the mixture of salts makes Adderall's effects smoother, with softer highs and lows, than those of other treatments for the same disorders.

There is little evidence, however, to support this claim for immediate-release Adderall. A recent patent application for Adderall (USP #6,384,020 [[1]] for details) was a pharmaceutical composition patent listing a rapid immediate release oral dosage form. No claim of increased or smooth drug delivery was made. A recent double-blind, placebo-controlled crossover study, conducted among children, indicated that Adderall behaved similarly to other immediate release amphetamines. The authors found that sustained-release dexamphetamine (the main isomeric-amphetamine component of Adderall) had a longer duration of action, and cost less than Adderall, though dexamphetamine was less effective in the first few hours of morning dosing. (see[[2]] for details)

Adderall is now sold in either an immediate-release tablet or an extended-release capsule, marketed as Adderall XR. Doses for both immediate-release and extended-release form come in 5mg, 10mg, 15mg, 20mg, 25mg, and 30mg increments.

Adderall XR utilizes the MicrotrolВ® delivery system to achieve the extended-release mechanism. This delivery system incorporates two beads: the first type of bead dissolves immediately and the second type releases four hours later. Maximum plasma concentration is achieved in seven hours, compared to regular Adderall IR (immediate-release) which reaches maximum plasma concentration within three hours. As a result of its high bioavailability, Adderall XR's effectiveness is not altered by food absorption in the GI tract. However, tmax (mean plasma concentration) is prolonged by 2.5 hours (using a standard high-fat meal as the control). Acidic beverages should not be taken with Adderall XR as they alter the pH balance of the stomach. However, parents may sprinkle Adderall XR on applesauce if a child does not like swallowing pills.

Effects

Adderall works by blocking the reuptake of dopamine and norepinephrine into the presynaptic neuron and increasing their release from the presynaptic neuron into the extraneuronal space. In other words, Adderall reverses the reuptake mechanism, turning it into a pump instead of a vacuum.

The increased flow of dopamine and norepinephrine into the extraneuronal space causes the brain, as one psychiatrist explains, to experience a more intense level of concentration, causing an increased ability to focus for extended periods of time, and a heightened interest in performing mental tasks.

Though rare, it is possible for Adderall to cause psychotic episodes at recommended doses.

Some people feel that they are less creative while taking Adderall, while others report that the focusing effect can aid in creative work. The famous Beat generation writer Jack Kerouac, for instance, is said to have written much of his classic On The Road in a span of three weeks, aided by dextroamphetamine (the active ingredient in Adderall) from Benzedrine inhalers; country music star Johnny Cash had a long period of amphetamine use in the 1960s; and mathematician Paul Erdos was noted for habitual use of prescription amphetamine throughout the final decades of his life; Smile was written by Brian Wilson and Van Dyke Parks with heavy amphetamine use, among others.

Negative Side Effects

Common side effects of Adderall include:

• insomnia
• anorexia (loss of appetite)
• diarrhea
• upset stomach
• vertigo
• headache
• nervousness
• mydriasis
• bruxism
• halitosis
• formication
• urinary retention
• pyrexia
• tachycardia
• tics

and

• Urticaria.

Performance-enhancing use and abuse

Because Adderall uses amphetamine stimulants to help the user concentrate for extended periods of time, many students today request Adderall from doctors in order to use it as a study aid, and it is increasingly popular on college campuses. Because of the appetite-suppressing properties of amphetamines, it is also sought after by those wishing to lose weight.

On the street, Adderall is sold illegally for $1 to $5 a pill (generally for a 20-30mg capsule). Slang terms for Adderall are: "ralls", "bennies", "amps", "addies", "jollies", "the A train" and in some regions of the U.S., "railguns" and "that'da boy(s)" (from noted increase in productivity). On some college campuses taking Adderall is know as "taking the A train", most likely inspired by the song "Take The A Train" by Duke Ellington. The 5mg and 10mg doses are also known in the northwest as "BBs", which is short for "Blueberries", named for their blue color. Heavier users tend to use the term "GBs", short for "goofballs", referring to the "goofed up" feeling from taking in excess of 100mg in a night.

Manufacturers

Adderall is manufactured by Catalytica Pharmaceuticals Inc. of Greenville, North Carolina and is distributed by Shire Pharmaceuticals. Generic equivalents (known to pharmacists as "amphetamine salts," "mixed amphetamines," or simply "amphetamines," inter alia) are also distributed in the United States by Mallinckrodt Pharmaceuticals and Ranbaxy Laboratories.

See also

• amphetamine
• methamphetamine
• methylphenidate
• dextroamphetamine
• HT-0712

External links

• Adderall XR for ADHD
• Report of study indicating Adderall more effective than Ritalin for ADHD treatment
• Article by a medical doctor outlining the benefits of Adderall as an ADHD medication
• Adderall Abuse
• Adderall a crutch for students pressed for study time
• Adderall XRВ® barred in Canada
• The Adderall Me - My romance with ADHD meds by Joshua Foer in Slate